Publications

1. Lin Z, Rong B, Wu M, Yan J, Hong T, Hou L,Tang X, Liu Q, Peng X, Chen Y*, Lan F*, Tong MH*. The KMT2 complexprotein ASH2L is required for meiotic prophase progression but dispensable for mitosis in differentiated spermatogonia. Development. 2025 Mar15;152(6):dev204630. doi: 10.1242/dev.204630.

2. Lin Z, Rong B, Lyu R*, Zheng Y, Chen Y, Yan J, WuM, Gao X, Tang F*, Lan F*, Tong MH*. SETD1B-mediated broadH3K4me3 controls proper temporal patterns of gene expression critical for spermatid development. Cell Res. 2025 May;35(5):345-361. doi:10.1038/s41422-025-01080-0.

3. Huang Z, He C, Wang G, Zhu M, Tong X, Feng Y, Zhang C, Dong S, Harim Y,Liu HK, Zhou W, Lan F*, Feng W*. Mutation of CHD7 impairsthe output of neuroepithelium transition that is reversed by the inhibition of EZH2. Mol Psychiatry. 2025 Mar 31. doi: 10.1038/s41380-025-02990-6.

4. Miao, B, Ge L, He C, Wang X, Wu J, Li X, Chen K, Wan J, Xing S, Ren L,Shi Z, Liu S, Hu Y, Chen J, Yu Y, Feng L, Flores NM, Liang Z, Xu X, Wang R, Zhou J, Fan J, Xiang B, Li E, Mao Y, Cheng J, Zhao K, Mazur PK*, Cai J* and Lan F* (2024). Cell Research. SMYD5 is a ribosomal methyltransferase thatcatalyzes RPL40 lysine methylation to enhance translation output and promote hepatocellular carcinoma.

5. Zhan W, Tian X, Zhang X, Xing S, Song W, Liu Q, Hao A, Hu Y, Zhang M,Ying T*, Chen Z*, Lan F*, Sun L*. Structural Study ofSARS-CoV-2 Antibodies Identifies a Broad-Spectrum Antibody That Neutralizes the Omicron Variant by Disassembling the Spike Trimer J. Virology 2022 Aug24;96(16):e0048022. doi: 10.1128/jvi.00480-22.

6. Liang Q, Wang S, Zhou X, Li Y, Xing S, Sha Y, Yang F, Huang W, Liu N, LiZ, Chen Y, Xu Y, Zhu P, Lan F*, Sun N*. Essential role ofMESP1-RING1A complex in cardiac differentiation. Dev Cell. 2022 Nov21;57(22):2533-2549.e7.

7. Xu W, He C, Kaye EG, Li J, Mu M, Nelson GM, Dong L, Wang J, Wu F, ShiYG, Adelman K*, Lan F*, Shi Y*, Shen H*. Dynamic control ofchromatin-associated m 6 A methylation regulates nascent RNA synthesis. Mol Cell. 2022 Mar 17;82(6):1156-1168

8. He C, Lan F*. RNAm 6 A meets transposable elements and chromatin Protein & Cell, 2021 Dec;12(12):906-910

9. Xu S, Wang S, Xing S, Yu D, Rong B, Gao H, Sheng M, Tan Y, Sun X, WangK, Xue K, Shi Z*, Lan F*. KDM5A suppresses PML-RARαtarget gene expression and APL differentiation through repressing H3K4me2. Blood Adv. 2021 Sep14;5(17):3241-3253.

10. Niu, C., Wang, S., Guo, J., Wei, X., Jia,M., Chen, Z., Gong, W., Qin, Y., Wang, X., Zhi, X., Lu, M., Chen, S., Gu, M., Zhang, J., Han, J.-D. J., Lan, F.*, and Meng, D*. BACH1recruits NANOG and histone H3 lysine 4 methyltransferase MLL/SET1 complexes to regulate enhancer–promoteractivity and maintains pluripotency. Nucleic Acids Research 2021https://doi.org/10.1093/nar/gkab03 (* Correspondence)

11. Rong B, Zhang Q, Wan J, Xing S, Dai R, LiY, Cai J, Xie J, Song Y, Chen J, Zhang L, Yan G, Zhang W, Gao H, Han JJ, Qu Q, Ma H*, Tian Y*, Lan F*. Ribosome 18S m6A Methyltransferase METTL5Promotes Translation Initiation and Breast Cancer Cell Growth. Cell Rep. 2020 Dec 22;33(12):108544.doi: 10.1016/j.celrep.2020.108544. PMID: 33357433.

12. Wan J, Xing S, Ding L, Wang Y, Gu C, Wu Y,Rong B, Li C, Wang S, Chen K, He C, Zhu D, Yuan S, Qiu C, Zhao C, Nie L, Gao Z, Jiao J, Zhang X, Wang X, Ying T, Wang H, Xie Y*, Lu Y*, Xu J*, Lan F*.Human-IgG-Neutralizing Monoclonal Antibodies Block the SARS-CoV-2 Infection. Cell Rep. 2020 Jul 21;32(3):107918.doi: 10.1016/j.celrep.2020.107918. Epub 2020 Jul 3. PMID: 32668215; PMCID:PMC7332464.

13. Yao Chen, Ruitu Lv, Bowen Rong, YuxuanZheng, Zhen Lin, Ruofei Dai, Xi Zhang, Nannan Xie, Siqing Wang, Fuchou Tang*, FeiLan* and Ming-Han Tong* (2020) Refined Spatial-temporal EpigenomicProfiling Reveals Intrinsic Connection between PRDM9-mediated H3K4me3 and the Fate of Double-stranded Breaks. CellResearch,2020 Mar;30(3):256-268. doi: 10.1038/s41422-020-0281-1. Epub 2020 Feb 11.

14. Wenqi Xu, Jiahui Li, Bowen Rong, Bin Zhao,Mei Wang, Ruofei Dai, Qilong Chen, Hang Liu, Zhongkai Gu, Shuxian Liu, Rui Guo,
Hongjie Shen*, Feizhen Wu*, Fei Lan*(2019) DNMT3A Reads and Connects Histone H3K36me2 to DNA methylation. Protein & Cell, 2020, Mar 11(3):230(2019 Nov 22 Early online, PMID 31758527)

15. Jianqing Wang*, Chenxi He, Peng Gao,Siqing Wang, Ruitu Lv, Huihui Zhou, Qidong Zhou, Ke Zhang, Jian Sun, Caibin Fan, Guanxiong Ding* and Fei Lan*(2019) HNF1B-mediated repression of SLUG is suppressed by EZH2 in aggressive prostate cancer. Oncogene, 2020 Feb(6) 1335-1346 (2019, Oct 21 Early Online, PMID 31636385)

16. Zhennan Shi, Siyuan Xu, Shenghui Xing, KeYao, Lei Zhang, Luxi Xue, Bisi Miao, Peng Zhou, Ming Wang, Guoquan Yan, Pengyuan Yang, Jing Liu, Zeping Hu*, FeiLan*（2019）Mettl17, aRegulator of Mitochondrial Ribosomal RNA Modifications, Is Required for the Translation of Mitochondrial Coding Genes. FASEBJ., 2019, Nov., 33(11), 13040-13050

17. Bisi Miao, Chuanyuan Wei, Zijun Qiao,Weiyu Han, Xiaoqiang Chai, Jiacheng Lu, Chao Gao, Ruizhao Dong, Dongmei Gao,
Cheng Huang, Aiwu Ke, Jian Zhou, Jia Fan, Guoming Shi*, Fei Lan*, Jiabin Cai*（2019）eIF3a MediatesHIF1α-dependent Glycolytic Metabolism in Hepatocellular Carcinoma Cells Through Translational Regulation Am. J. Cancer Research,2019, 9 (5) 1079-1090

18. Xiaoyang Dou, Jerome D Boyd-Kirkup, JosephMcDermott, Xiaoli Zhang, Fang Li, Bowen Rong, Rui Zhang, Bisi Miao, Peilin Chen, Hao Cheng, Jianhuang Xue, David Bennett, Jiemin Wong , Fei Lan, Jing-Dong J Han. (2019) TheStrand-Biased Mitochondrial DNA Methylome and Its Regulation by DNMT3A. Genome Research, 29 (10), 1622-1634,Oct 2019

19. Xi Jin, Xiao-En Xu, Yi-Zhou Jiang, Yi-RongLiu, Wei Sun, Ya-Jie Guo, Yi-Xing Ren, Wen-Jia Zuo, Xin Hu, Sheng-Lin Huang, Hong-Jie Shen, Fei Lan, Yun-Fei He,Guo-Hong, Gen-Hong Di, Xiang-Huo He, Da-Qiang Li, Suling Liu, Ke-Da Yu, Zhi-Ming Shao （2019） The EndogenousRetrovirus-Derived Long Noncoding RNA TROJAN Promotes Triple-Negative Breast Cancer Progression via ZMYND8 Degradation. ScienceAdvances, 5 (3), eaat9820, 2019 Mar 6 eCollection

20. Meng-Meng Zhang, Na Liu, Yuan-Liang Zhang,Bowen Rong, Xiao-Lin Wang, Chun-Hui Xu, Yin-Yin Xie, Shuhong Shen, Jiang Zhu, Stephen D Nimer, Zhu Chen, Sai-Juan Chen, Robert G Roeder, Fei Lan, Lan Wang, Qiu-Hua Huang, Xiao-Jian Sun （2019） Destabilization ofAETFC Through C/EBPα-mediated Repression of LYL1 Contributes to t(8;21) Leukemic Cell Differentiation. Leukemia, 33(7), 1822-1827, Jul 2019

21. Liu N, Song J, Xie Y, Wang XL, Rong B, ManN, Zhang MM, Zhang Q, Gao FF, Du MR, Zhang Y, Shen J, Xu CH, Hu CL, Wu JC, Liu P, Zhang YL, Xie YY, Liu P, Huang JY, Huang QH, Lan F, Shen S, Nimer SD, Chen Z, Chen SJ, Roeder RG, Wang L, SunXJ. Different roles of E proteins in t(8;21) leukemia: E2-2 compromises the function of AETFC and negatively regulates leukemogenesis. Proc Natl Acad Sci U S A. 2019 Jan 15;116(3):890-899. doi:10.1073/pnas.1809327116. Epub 2018 Dec 28.

22. Ma H, Wang X, Cai J, Dai Q, Natchiar SK,Lv R, Chen K, Lu Z, Chen H, Shi YG, LanF, Fan J, Klaholz BP, Pan T, Shi Y, He C. N6-Methyladenosinemethyltransferase ZCCHC4 mediates ribosomal RNA methylation. Nat Chem Biol. 2019 Jan;15(1):88-94.doi: 10.1038/s41589-018-0184-3. Epub 2018 Dec 10.

23. Chen LL, Lin HP, Zhou WJ, He CX, Zhang ZY,Cheng ZL, Song JB, Liu P, Chen XY, Xia YK, Chen XF, Sun RQ, Zhang JY, Sun YP, Song L, Liu BJ, Du RK, Ding C, LanF, Huang SL, Zhou F, Liu S, Xiong Y, Ye D, Guan KL. SNIP1 Recruits TET2 toRegulate c-MYC Target Genes and Cellular DNA Damage Response. Cell Rep. 2018 Nov6;25(6):1485-1500.e4. doi: 10.1016/j.celrep.2018.10.028.

24. Zhao B, Xu W, Rong B, Chen G, Ye X, Dai R,Li W, Chen J, Cai J, Song L, Luo ZQ, Zeng R, Shi Y, Han JJ, Lan F*. H3K14me3 Genomic Distributionsand its regulation by KDM4 family demethylases. Cell Res. 2018 Nov;28(11):1118-1120. Epub 2018 Oct 18. (*Correspondence)

25. Xu S, Zhou C, Liu R, Zhu Q, Xu Y*, Lan F*, Zha X*. Optimization of 5-arylidenebarbiturates as potent, selective, reversible LSD1 inhibitors for the treatment of acute promyelocytic leukemia. BioorgMed Chem. 2018 Sep 15;26(17):4871-4880. doi: 10.1016/j.bmc.2018.08.026.Epub 2018 Aug 22. (* Correspondence)

26. Wu D, Hu D, Chen H, Shi G, Fetahu IS, WuF, Rabidou K, Fang R, Tan L, Xu S, Liu H, Argueta C, Zhang L, Mao F, Yan G, Chen J, Dong Z, Lv R, Xu Y, Wang M, Ye Y, Zhang S, Duquette D, Geng S, Yin C, Lian CG, Murphy GF, Adler GK, Garg R, Lynch L, Yang P, Li Y, Lan F, Fan J, Shi Y, Shi YG.Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer. Nature. 2018Jul;559(7715):637-641. doi: 10.1038/s41586-018-0350-5. Epub 2018 Jul 18.

27. Cheng H, Xuan H, Green CD, Han Y, Sun N,Shen H, McDermott J, Bennett DA, LanF, Han JJ. Repression of human and mouse brain inflammaging transcriptomeby broad gene-body histone hyperacetylation. Proc Natl Acad Sci U S A. 2018 Jul 17;115(29):7611-7616. doi:10.1073/pnas.1800656115. Epub 2018 Jul 2.

28. Zuo X, Rong B, Li L, Lv R, Lan F*, Tong MH*. The histonemethyltransferase Setd2 is required for expression of acrosin-binding protein 1 and protamines and essential for spermiogenesis in mice. J. Boil. Chem. 2018 Jun 15;293(24):9188-9197. Epub 2018 May1. (* Correspondence)

29. Wen J, Lv R, Ma H, Shen H, He C, Wang J,Jiao F, Liu H, Yang P, Tan L, Lan F,Shi YG, He C, Shi Y, Diao J. Zc3h13 Regulates Nuclear RNA m6A Methylation and Mouse Embryonic Stem Cell Self-Renewal. MolCell. 2018 Mar 15;69(6):1028-1038.e6. doi:

30. Xi J, Xu S, Zhang L, Bi X, Ren Y, Liu YC,Gu Y, Xu Y, Lan F*, Zha X*.Design, synthesis and biological activity of 4-(4-benzyloxy)phenoxypiperidines as selective and reversible LSD1 inhibitors. Bioorg Chem. 2018 Aug;78:7-16. doi: 10.1016/j.bioorg.2018.02.016.Epub 2018 Feb 16. (* Correspondence)

31. Xi J, Xu S, Wu L, Ma T, Liu R, Liu YC,Deng D, Gu Y, Zhou J, Lan F*,Zha X*. Design, synthesis and biological activity of 3-oxoamino-benzenesulfonamides as selective and reversible LSD1 inhibitors. Bioorg Chem. 2017 Jun;72:182-189. doi:10.1016/j.bioorg.2017.04.006. Epub 2017 Apr 13. (* Correspondence)

32. Shen H, Xu W, Lan F*. Histone lysine demethylases in mammalian embryonicdevelopment. (Review) Experimental &Molecular Medicine 2017 Apr 28;49(4):e325 (* Correspondence)

33. Ma C, Karwacki-Neisius V, Tang H, Li W,Shi Z, Hu H, Xu W, Wang Z, Kong L, Lv R, Fan Z, Zhou W, Yang P, Wu F, Diao J, Tan L, Shi YG, Lan F*, Shi Y*. Nono,a Bivalent Domain Factor, Regulates Erk Signaling and Mouse Embryonic Stem Cell Pluripotency. Cell Rep. 2016 Oct18;17(4):997-1007. (* Correspondence)

34. Kong L, Tan L, Lv R, Shi Z, Xiong L, Wu F,Rabidou K, Smith M, He C, Zhang L, Qian Y, Ma D, Lan F, Shi Y, Shi YG. A primary role of TET proteins inestablishment and maintenance of De Novo bivalency at CpG islands. Nucleic Acids Res. 2016 Oct14;44(18):8682-8692. Epub 2016 Jun 10.

35. Li N, Li Y, Lv J, Zheng X, Wen H, Shen H,Zhu G, Chen TY, Dhar SS, Kan PY, Wang Z, Shiekhattar R, Shi X, Lan F, Chen K, Li W, Li H, Lee MG.ZMYND8 Reads the Dual Histone Mark H3K4me1-H3K14ac to Antagonize the Expression of Metastasis-Linked Genes. Mol Cell.2016 Aug 4;63(3):470-84.

36. Gehling VS, Bellon SF, Harmange JC,LeBlanc Y, Poy F, Odate S, Buker S, LanF, Arora S, Williamson KE, Sandy P, Cummings RT, Bailey CM, Bergeron L, MaoW, Gustafson A, Liu Y, VanderPorten E, Audia JE, Trojer P, Albrecht BK. Identification of potent, selective KDM5 inhibitors. Bioorg Med Chem Lett. 2016 Sep 1;26(17):4350-4. doi:10.1016/j.bmcl.2016.07.026. Epub 2016 Jul 19.

37. Vinogradova M, Gehling VS, Gustafson A,Arora S, Tindell CA, Wilson C, Williamson KE, Guler GD, Gangurde P, Manieri W,
Busby J, Flynn EM, Lan F, KimHJ, Odate S, Cochran AG, Liu Y, Wongchenko M, Yang Y, Cheung TK, Maile TM, Lau
T, Costa M, Hegde GV, Jackson E, Pitti R, Arnott D, Bailey C, Bellon S, Cummings RT, Albrecht BK, Harmange JC, Kiefer JR, Trojer P, Classon M. An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells. Nat Chem Biol. 2016 Jul;12(7):531-8.doi: 10.1038/nchembio.2085. Epub 2016 May 23.

38. Shen H, Xu W, Guo R, Rong B, Gu L, Wang Z,He C, Zheng L, Hu X, Shao Z-M, Yang PY, Wu FZ, Shi YG, Shi Y* and Lan F*. Suppression of EnhancerOver-activation by a RACK7-Histone Demethylase Complex. Cell 2016 Apr7;165(2):331-42. (* Correspondence)

39. Yang L, Lian X, Zhang W, Guo J, Wang Q, LiY, Chen Y, Yin X, Yang P, Lan F*, HeQY*, Zhang G*, Wang T*. Finding Missing Proteins from the Epigenetically Manipulated Human Cell with Stringent Quality Criteria. J Proteome Res. 2015 Sep 4;14(9):3645-57. Epub 2015 Aug 6. (*Correspondence)

40. Zhu L, Lv R, Kong L, Cheng H*, Lan F*, Li X*. Genome-Wide Mapping of5mC and 5hmC Identified Differentially Modified Genomic Regions in Late-Onset Severe Preeclampsia: A Pilot Study. PLoSOne. 2015 Jul 27;10(7) (* Correspondence)

41. Liu H, Tang Y, Liu X, Zhou Q, XiaoX, Lan F, Li X, Hu R, Xiong Y,Peng T. 14-3-3 tau (YWHAQ) gene promoter hypermethylation in human placenta of preeclampsia. Placenta. 2014Dec;35(12):981-8.

42. Lan F*, ShiY*. Histone H3.3 and Cancer: a potential reader connection. (Review) Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):6814-9. doi: 10.1073/pnas.1418996111. Epub 2014 Dec 1. (* Correspondence)

43. Guo, R., Zheng, LJ., Park, J.W., Xu, WQ.,Chen, H., Qiu, JS., Lv RT., Wang, ZT., Yang, PY., Wu, FZ., Shi, XB., Fu, XD.,
Shi, G.YJ., Xing, Y*., Lan, F*., and Shi, Y*. BS69/ZMYND11 Reads and ConnectsHistone H3.3 Lysine 36 Trimethylation-Decorated Chromatin to Regulated Pre-mRNA Processing. Mol Cell. 2014 Oct23;56(2):298-310. (* Correspondence)

44. Chen H,Ma H, Inuzuka H, Diao J, Lan F, ShiYG, Wei W, Shi Y. DNA damage regulates UHRF1 stability via the SCF(β-TrCP) E3 ligase. Mol Cell Biol. 2013Mar;33(6):1139-48.

45. TzatsosA, PaskalevaP, Ferrari F, Deshpande V, Stoykova S, Lan F, Contino G, Trojer P, Park P, Bardeesy N. KDM2B controlstumorigenesis in pancreatic cancer via Polycomb-dependent and -independent
transcriptional programs. Journal ofClinical Investigation 2013 Feb 1;123(2):727-39.

46. Kim HG,Kim HT*, Leach NT*, Lan F*, UllmannR, Silahtaroglu A, Kurth I, Nowka A, Seong IS, Shen Y, Talkowski ME, Ruderfer
D, Lee JH, Glotzbach C, Ha K, Kjaergaard S, Levin AV, Romeike BF, Kleefstra T, Bartsch O, Elsea SH, Jabs EW, MacDonald ME, Harris DJ, Quade BJ, Ropers HH, Shaffer LG, Kutsche K, Layman LC, Tommerup N, Kalscheuer VM, Shi Y, Morton CC, Kim CH, Gusella JF. Translocations disrupting PHF21A in the Potocki-Shaffer-syndrome region are associated with intellectual disability and craniofacial anomalies. Am J Hum Genet. 2012Jul 13;91(1):56-72. Epub 2012 Jul 5. (* Co-second)

47. Ma H,Chen H, Guo X, Wang Z, Sowa ME, Zheng L, Hu S, Zeng P, Guo R, Diao J, Lan F, Harper JW, Shi YG, Xu Y,Shi Y. M phase phosphorylation of the epigenetic regulator UHRF1 regulates its physical association with the deubiquitylase USP7 and stability. Proc Natl Acad Sci U.S.A. 2012 Mar 27;109 (13) 4828-33.

48. RajakumaraE, Wang Z, Ma H, Hu L, Chen H, Lin Y, Guo R, Wu F, Li H, Lan F, Shi YG, Xu Y, Patel DJ, Shi Y. PHD fingerrecognition of unmodified histone H3R2 links UHRF1 to regulation of euchromatic gene expression. Mol Cell. 2011 Jul22;43(2):275-84.

49. Fang R,Barbera AJ, Xu Y, Rutenberg M, Leonor T, Bi Q, Lan F, Mei P, Yuan GC, Lian C, Peng J, Cheng D, Sui G, Kaiser UB,Shi Y, Shi YG. Human LSD2/KDM1b/AOF1 regulates gene transcription by modulating intragenic H3K4me2 methylation. MolCell. 2010 Jul 30;39(2):222-33.

50. Qi HH,Sarkissian M, Hu GQ, Wang Z, Bhattacharjee A, Gordon DB, Gonzales M, Lan F, Ongusaha PP, Huarte M, YaghiNK, Lim H, Garcia BA, Brizuela L, Zhao K, Roberts TM, Shi Y. Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development. Nature. 2010 Jul 22;466(7305):503-7.

51. Tsai MC,Manor O, Wan Y, Mosammaparast N, Wang JK, LanF, Shi Y, Segal E, Chang HY.Long noncoding RNA as modular scaffold ofhistone modification complexes. Science.2010 Aug 6;329(5992):689-93.

52. Lan, F*. and Shi. Y* Epigenetic regulation: methylation ofhistone and non-histone proteins. SciChina C Life Sci, 2009. 52(4): p. 311-22. (* Correspondence)

53. Hyung-GooKim; Ingo Kurth; Fei Lan; IreneMeliciani; Wolfgang Wenzel; Soo Hyun Eom; Gil Bu Kang; Georg Rosenberger; Mustafa Tekin; Metin Ozata; David Bick; Richard Sherins; Steven Walker; Yang Shi; James Gusella; Lawrence C Layman. Mutations in CHD7, encoding a chromatin remodeling protein, causeidiopathic hypogonadotropic hypogonadism and Kallmann syndrome. American Journal of Human Genetics. 2008Oct;83(4):511-9. Epub 2008 Oct 2.

54. Lan F*, Nottke AC*, ShiY. Mechanisms involved in the regulation of histone lysine demethylases. Curr Opin Cell Biol. 2008Jun;20(3):316-25. Epub 2008 Apr 25. (* Co-first)

55. Lan F, Bayliss PE, RinnJL, Whetstine JR, Wang JK, Chen S, Iwase S, Alpatov R, Issaeva I, Canaani E, Roberts TM, Chang HY, Shi Y. A histoneH3 lysine 27 demethylase regulates animal posterior development. Nature Article. 2007 Oct11;449(7163):689-94. Epub 2007 Sep 12.

56. Lan F*, Collins RE*, DeCegli R, Alpatov R, Horton JR, Shi X, Gozani O, Cheng X, Shi Y. Recognition of unmethylated histone H3 lysine 4 links BHC80 to LSD1-mediated gene repression. Nature. 2007 Aug 9;448(7154):718-22. (*Co-first)

57. Chen Z,Zang J, Kappler J, Hong X, Crawford F, Wang Q, Lan F, Jiang C, Whetstine J, Dai S, Hansen K, Shi Y, Zhang G.Structural basis of the recognition of a methylated histone tail by JMJD2A. Proc Natl Acad Sci U S A. 2007 Jun26;104(26):10818-23. Epub 2007 Jun 13.

58. HuarteM, Lan F, Kim T, Vaughn MW,Zaratiegui M, Martienssen RA, Buratowski S, Shi Y. The fission yeast Jmj2 reverses histone H3 Lysine 4 trimethylation. J Biol Chem. 2007 Jul 27;282(30):21662-70. Epub 2007 Jun 5.

59. Lan F, Zaratiegui M,Villén J, Vaughn MW, Verdel A, Huarte M, Shi Y, Gygi SP, Moazed D, Martienssen RA, Shi Y. S. pombe LSD1 homologs regulate heterochromatin propagation and euchromatic gene transcription. MolCell. 2007 Apr 13;26(1):89-101.

60. IwaseS*, Lan F*, Bayliss P, de laTorre-Ubieta L, Huarte M, Qi HH, Whetstine JR, Bonni A, Roberts TM, Shi Y. The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases. Cell. 2007 Mar23;128(6):1077-88. Epub 2007 Feb 22. (* Co-first)

61. Zhu JD,Fei Q, Wang P, Lan F, Mao da Q,Zhang HY, Yao XB. Transcription of the putative tumor suppressor gene HCCS1 requires binding of ETS-2 to its consensus near the transcription start site. Cell Res. 2006 Sep;16(9):780-96.

62. Shi X,Hong T, Walter KL, Ewalt M, Michishita E, Hung T, Carney D, Peña P, Lan F, Kaadige MR, Lacoste N, Cayrou C,Davrazou F, Saha A, Cairns BR, Ayer DE, Kutateladze TG, Shi Y, Côté J, Chua KF, Gozani O. ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. Nature. 2006 Jul6;442(7098):96-9. Epub 2006 May 21.

63. WhetstineJR, Nottke A, Lan F, Huarte M,Smolikov S, Chen Z, Spooner E, Li E, Zhang G, Colaiacovo M, Shi Y. Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases. Cell. 2006 May 5;125(3):467-81. Epub2006 Apr 6.

64. Shi YJ,Matson C*, Lan F*, Iwase S, Baba T,Shi Y. Regulation of LSD1 histone demethylase activity by its associated factors. Mol Cell. 2005 Sep16;19(6):857-64. (* Co-second)

65. Shi Y, Lan F, Matson C, Mulligan P, WhetstineJR, Cole PA, Casero RA, Shi Y. Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell.2004 Dec 29;119(7):941-53.

66. Shi Y,Sawada J, Sui G, Affar el B, Whetstine JR,Lan F, Ogawa H, Luke MP, Nakatani Y, Shi Y. Coordinated histonemodifications mediated by a CtBP co-repressor complex. Nature. 2003 Apr 17;422(6933):735-8.

67. Shen Z,Wen XF, Lan F, Shen ZZ, Shao ZM. Thetumor suppressor gene LKB1 is associated with prognosis in human breast carcinoma. Clin Cancer Res. 2002Jul;8(7):2085-90.

68. Zhao X,Li J, He Y, Lan F, Fu L, Guo J, ZhaoR, Ye Y, He M, Chong W, Chen J, Zhang L, Yang N, Xu B, Wu M, Wan D, Gu J. A novel growth suppressor gene on chromosome 17p13.3 with a high frequency of mutation in human hepatocellular carcinoma.Cancer Res. 2001 Oct 15;61(20):7383-7.

69. Hu PR,Yu L, Zhang M, Zheng LH, Lan F, FuQ, Zhao SY. Cloning, tissue expression pattern characterization and chromosome
localization of human peptide methionine sulfoxide reductase cDNA. Chinese Science Bulletin, 2001 Vol. 45,2251-7.

70. Lan F, Yu L, Hu PR, MaoDQ, Li XQ, Zhang M, Huang H, Zhao SY. Cloning, tissue expression pattern, and chromosome localization of human protein kinase B gamma gene. Chinese Science Bulletin, 2001 Vol. 45,1832-9.